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Functional selective FPR1 signaling in favor of an activationof the neutrophil superoxide generating NOX2 complex

Inicure lead compound characterised as a specific agonist for FPR1, which displays a biased signalling profile that leads to a functional selective activating of the human neutrophils class (https://doi.org/10.1002/JLB.2HI0520-317R).   

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GoWest 29-30 January

Looking forward to meet research partners and investors at the GoWest – Nordic capital forum 29-30 January.

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections

The critical role and immunological mechanism of activation of FPR and the significance of NADPH oxidase 2 (NOX2)-derived